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Severe Hypoglycemia: Emergency Signs Every Person with Diabetes Should Know

05 Sep 2025 K Sreekumaran Nair, M.D., Ph.D.

Severe Hypoglycemia: Emergency Signs Every Person with Diabetes Should Know

Hypoglycemia, or low blood sugar, is a common complication for individuals with diabetes, especially those managing their condition with insulin or certain oral medications. While mild hypoglycemia can often be self-treated, severe hypoglycemia is a dangerous situation requiring immediate intervention. Recognizing the emergency signs of severe hypoglycemia is critical for people with diabetes and their loved ones. This article will delve into the signs, symptoms, and steps you should take during a hypoglycemic emergency, ensuring you are prepared to act quickly and effectively.

Understanding Hypoglycemia and its Progression

Before diving into the emergency signs, it’s essential to understand what hypoglycemia is and how it can progress. Hypoglycemia occurs when the glucose (sugar) level in your blood drops too low. For people with diabetes, this typically means a blood sugar level below 70 mg/dL.

Here’s how it often unfolds:

  • Mild Hypoglycemia: Initial symptoms might include shakiness, sweating, anxiety, irritability, and hunger.
  • Moderate Hypoglycemia: As blood sugar continues to fall, symptoms may worsen, leading to confusion, difficulty concentrating, slurred speech, and blurred vision.
  • Severe Hypoglycemia: This is a medical emergency characterized by the inability to self-treat, loss of consciousness, seizures, or coma. It requires immediate assistance from others.

| Stage of Hypoglycemia | Blood Sugar Level (mg/dL) | Common Symptoms | Treatment | | :--------------------- | :------------------------ | :---------------------------------------------- | :------------------------------------------------------------- | | Mild | 70-55 | Shakiness, Sweating, Anxiety, Hunger | 15-20 grams of fast-acting carbohydrates; recheck blood sugar after 15 minutes | | Moderate | 54-40 | Confusion, Difficulty Concentrating, Slurred Speech | 15-20 grams of fast-acting carbohydrates; recheck blood sugar after 15 minutes; assistance might be needed | | Severe | Below 40 | Loss of Consciousness, Seizures, Coma | Glucagon injection; call emergency services immediately |

Key Emergency Signs of Severe Hypoglycemia

The defining characteristic of severe hypoglycemia is the inability of the individual to treat themselves due to altered mental status or unconsciousness. Here are the key emergency signs to be aware of: How To Manage Blood Sugar Naturally A Beginner S Guide

  • Loss of Consciousness: This is perhaps the most alarming sign. The person may become unresponsive, unable to wake up, or only partially alert.
  • Seizures: Severe drops in blood sugar can trigger seizures. These may manifest as uncontrolled shaking, muscle spasms, and loss of awareness.
  • Inability to Swallow or Follow Simple Commands: Even if the person is conscious, they may be unable to swallow glucose tablets or juice or understand simple instructions. This indicates a significant impairment in cognitive function.
  • Unusual or Erratic Behavior: Sometimes, severe hypoglycemia can present as sudden and inexplicable behavioral changes, such as aggression, confusion, or disorientation, even without complete loss of consciousness.
  • Profound Weakness or Incoordination: Extreme muscle weakness or the inability to coordinate movements can also signal severe hypoglycemia. The person may stagger, fall, or be unable to stand.

Immediate Actions to Take During a Hypoglycemic Emergency

When faced with someone experiencing a hypoglycemic emergency, swift action is essential. Here's a step-by-step guide:

  1. Assess the Situation: First, determine if the person is conscious and able to swallow.
  2. If Conscious and Able to Swallow: Give them a fast-acting source of glucose, such as glucose tablets, juice, regular (non-diet) soda, or honey. Aim for 15-20 grams of carbohydrates.
  3. If Unconscious or Unable to Swallow:
    • Administer Glucagon: If you have access to a glucagon emergency kit and know how to use it, administer the glucagon injection as directed. Glucagon is a hormone that raises blood sugar levels.
    • Call Emergency Services (911 or Your Local Emergency Number): Even after administering glucagon, it's crucial to call for professional medical assistance.
    • Do Not Attempt to Give Food or Liquid by Mouth: This could lead to choking.
  4. Monitor the Person: Whether you administer glucose or glucagon, carefully monitor the person’s condition. After glucagon, it may take 10-15 minutes for them to regain consciousness. Be prepared to provide details to emergency responders when they arrive.
  5. Provide Information: When emergency services arrive, inform them that the person has diabetes and was experiencing severe hypoglycemia. Share details about any medications they are taking and the steps you took to assist them.

| Action | When to Perform | Rationale | | :---------------------------------------------- | :---------------------------------------------------------- | :-------------------------------------------------------------------------------- | | Assess consciousness and swallowing ability | Immediately upon noticing signs of potential hypoglycemia | Determines the appropriate course of action | | Give fast-acting glucose (if conscious) | If the person is conscious and able to swallow | Provides a rapid source of sugar to raise blood glucose levels | | Administer Glucagon (if unconscious) | If the person is unconscious and you have glucagon | Triggers the release of stored glucose from the liver | | Call Emergency Services | Regardless of consciousness or administration of glucagon | Ensures professional medical assistance and transportation to a hospital if needed | | Monitor and provide information to responders | Throughout the event and upon arrival of emergency services | Provides critical details for proper diagnosis and treatment |

Prevention is Key: Managing Diabetes Effectively

While knowing how to respond to severe hypoglycemia is essential, the best approach is to prevent it from happening in the first place. Here are some strategies for effectively managing diabetes to minimize the risk of severe low blood sugar:

  • Regular Blood Sugar Monitoring: Check your blood sugar levels frequently, especially before meals, before bed, and after exercise.
  • Consistent Meal Timing: Eat meals and snacks at regular times to avoid significant fluctuations in blood sugar.
  • Medication Adherence: Take your diabetes medications as prescribed by your doctor. Understand how your medications work and potential side effects, including hypoglycemia.
  • Carbohydrate Counting: Learn how to count carbohydrates in your meals to accurately match your insulin dosage, if applicable.
  • Exercise Precautions: Adjust your insulin dose or consume extra carbohydrates before, during, or after exercise to prevent hypoglycemia.
  • Alcohol Awareness: Be aware that alcohol can lower blood sugar levels, especially when consumed on an empty stomach. Consume alcohol in moderation and with food.
  • Educate Family and Friends: Teach your loved ones about the signs of hypoglycemia and how to administer glucagon. Ensure they know where your glucagon kit is located.
  • Wear a Medical Alert: Consider wearing a medical identification bracelet or necklace indicating you have diabetes. This can help emergency responders provide appropriate care if you are unable to communicate.
  • Continuous Glucose Monitoring (CGM): Talk to your doctor about whether a CGM device is right for you. These devices continuously track your blood sugar levels and can alert you to trends and potential low blood sugar events before they become severe.

Glucagon: A Life-Saving Tool

Glucagon is a prescription medication designed to quickly raise blood sugar levels in cases of severe hypoglycemia when a person is unable to take sugar orally. It's crucial for individuals at risk of severe hypoglycemia to have a glucagon emergency kit readily available and for their family and friends to know how to administer it. A Step By Step Guide On How To Perform A Blood Sugar Test At Home

Types of Glucagon Kits:

  • Traditional Glucagon Injection: This kit typically contains a vial of powdered glucagon and a syringe with a liquid diluent. You must mix the two before injecting the medication.
  • Nasal Glucagon (Baqsimi): This is a newer formulation that is administered as a nasal spray, making it easier to use in emergency situations as it doesn't require mixing or injection.
  • Premixed Glucagon Pen (Gvoke HypoPen): This is a prefilled autoinjector that delivers a fixed dose of glucagon. It's easy to use, even for those without medical training.

Important Considerations for Glucagon Use:

  • Storage: Store glucagon kits at room temperature, away from direct sunlight and extreme temperatures. Check the expiration date regularly and replace expired kits.
  • Training: Educate family members, friends, and caregivers on how to properly administer glucagon, including reading the instructions and practicing with a trainer device (if available).
  • Side Effects: Common side effects of glucagon include nausea, vomiting, and headache. Turn the person on their side to prevent choking if they vomit.
  • Follow-Up: Even after administering glucagon and the person regains consciousness, it’s essential to seek medical attention to determine the underlying cause of the hypoglycemia and adjust their diabetes management plan accordingly.

Staying Prepared and Informed

Severe hypoglycemia is a serious complication of diabetes that can have life-threatening consequences. Recognizing the emergency signs, acting quickly, and knowing how to administer glucagon are crucial steps in managing a hypoglycemic emergency. More importantly, consistent and effective diabetes management is the key to preventing severe low blood sugar episodes. By diligently monitoring blood sugar levels, adhering to medication regimens, maintaining a healthy lifestyle, and educating yourself and your loved ones, you can significantly reduce the risk of severe hypoglycemia and live a healthier, more confident life with diabetes.

Consult your healthcare provider for personalized advice and guidance on managing your diabetes and preventing hypoglycemia. They can provide you with a tailored treatment plan and ensure you have the necessary tools and knowledge to stay safe. How To Lower Your Blood Sugar Levels Naturally With A Diabetic Diet

References and Further Reading