Severe Hypoglycemia: Emergency Signs and What Every Person with Diabetes Should Know
05 Sep 2025 Aoife M. Egan, M.B., B.Ch., Ph.D.
Severe Hypoglycemia: Emergency Signs and What Every Person with Diabetes Should Know
Severe hypoglycemia, or dangerously low blood sugar, is a critical condition that can occur in individuals with diabetes. Recognizing the signs, understanding the risks, and knowing how to respond can be life-saving. This article outlines the emergency signs of severe hypoglycemia, explains why it happens, and provides essential knowledge for every person with diabetes to manage and prevent this serious event.
Why Severe Hypoglycemia Matters

Hypoglycemia occurs when blood glucose levels drop too low, typically below 70 mg/dL (3.9 mmol/L). While mild to moderate hypoglycemia can often be managed with quick-acting carbohydrates, severe hypoglycemia represents a more profound and dangerous state where the individual's cognitive and physical functions are significantly impaired. It can lead to loss of consciousness, seizures, coma, and, in rare cases, even death.
For individuals with diabetes, particularly those using insulin or certain oral medications that increase insulin secretion, understanding and preventing severe hypoglycemia is crucial for their safety and well-being.
Recognizing Emergency Signs of Severe Hypoglycemia
Severe hypoglycemia is a medical emergency requiring immediate intervention. Knowing the signs can allow you or those around you to act swiftly. Here are the key emergency signs to watch for:
- Loss of Consciousness: The individual becomes unresponsive and unable to follow commands.
- Seizures: Uncontrolled electrical disturbances in the brain causing convulsions.
- Confusion and Disorientation: Marked difficulty in thinking clearly, remembering things, or knowing where they are.
- Inability to Swallow or Take Oral Medication: The individual is unable to safely consume food or drink.
- Unusual or Aggressive Behavior: Sudden and uncharacteristic changes in behavior, including irritability or aggression.
These signs indicate that the brain is not receiving enough glucose to function properly. Immediate action is necessary to raise blood sugar levels and prevent potentially irreversible damage. The Ultimate Blood Sugar Test Guide From Finger Pricks To Cgms
Example Scenario:
Imagine you're having dinner with a friend who has diabetes. Suddenly, they start slurring their words, appear confused, and then become unresponsive. This could be a sign of severe hypoglycemia, and you would need to take immediate action, as outlined in the next sections.
Immediate Actions to Take During a Severe Hypoglycemic Event
When someone experiences severe hypoglycemia, prompt and decisive action is crucial. Here’s a step-by-step guide:
-
Assess the Situation: First, ensure the person is safe from any immediate harm (e.g., move them away from a busy road). Check for medical identification, such as a MedicAlert bracelet, which can provide important information about their diabetes.
-
Do Not Attempt to Give Food or Drink if Unconscious: If the person is unconscious, do NOT try to force-feed them. This can cause choking.
-
Administer Glucagon (if available): Glucagon is a hormone that stimulates the liver to release stored glucose into the bloodstream. If you know how to administer glucagon and it is available (either a glucagon emergency kit or a nasal glucagon spray), inject it according to the instructions provided.
- Glucagon Injection: Typically injected into the thigh, arm, or buttock. Follow the kit's specific directions for reconstitution and injection.
- Nasal Glucagon: Administered by spraying into one nostril.
| Type of Glucagon | Administration Method | | ---------------------- | ------------------------------------------------------------ | | Injection | Requires mixing and injection using a needle and syringe | | Nasal Spray (e.g., Baqsimi) | Ready-to-use nasal spray; no mixing or injection required |
-
Call for Emergency Medical Help: Whether you administer glucagon or not, call your local emergency number (e.g., 911 in the US) immediately. Severe hypoglycemia requires professional medical evaluation, as blood sugar levels can rebound erratically.
-
Monitor the Person: Stay with the person and monitor their breathing and responsiveness until medical help arrives.
-
After Glucagon Administration: If the person regains consciousness after glucagon administration and is able to swallow, give them a fast-acting source of carbohydrates such as juice, regular (non-diet) soda, or glucose tablets. Follow this with a longer-acting source of carbohydrates like crackers or a sandwich to stabilize their blood sugar.
Important Note:
Even if the person seems to recover after glucagon administration, it is still imperative to seek medical attention. The underlying cause of the hypoglycemia needs to be investigated, and further complications may arise.
Understanding the Causes and Risk Factors of Severe Hypoglycemia
Knowing the reasons behind severe hypoglycemia can help people with diabetes, along with their caregivers, take proactive steps to prevent it. Here are some common causes and risk factors:
- Excessive Insulin Dose: Taking too much insulin relative to food intake or physical activity.
- Missed or Delayed Meals: Skipping meals or delaying eating after taking insulin or diabetes medication.
- Intense Exercise: Engaging in strenuous physical activity without adjusting medication or increasing carbohydrate intake.
- Alcohol Consumption: Alcohol can impair the liver's ability to release glucose, especially when consumed without food.
- Kidney or Liver Disease: Impaired kidney or liver function can affect glucose metabolism and medication clearance, increasing the risk of hypoglycemia.
- Medication Interactions: Certain medications can interact with diabetes drugs, leading to increased insulin sensitivity or reduced glucose production.
- Impaired Awareness of Hypoglycemia: Some people lose the ability to recognize the early warning signs of hypoglycemia (hypoglycemia unawareness).
Case Example:
Consider a person with type 1 diabetes who injects their usual dose of insulin but then gets unexpectedly delayed and misses lunch. This situation can lead to a rapid drop in blood sugar, potentially resulting in severe hypoglycemia.
Key Strategies to Mitigate Risk:
- Regular Blood Glucose Monitoring: Frequent monitoring, especially before meals, after exercise, and before bedtime, is crucial.
- Adjusting Insulin Doses: Work closely with your healthcare provider to adjust insulin doses based on food intake, activity levels, and blood glucose readings.
- Consistent Meal Timing: Maintain a regular meal schedule and avoid skipping meals.
- Carbohydrate Counting: Learn to accurately estimate the carbohydrate content of foods to match insulin doses.
- Medical Identification: Wear a medical ID bracelet or necklace indicating you have diabetes and any specific medication needs.
- Educating Family and Friends: Ensure that family members, friends, and coworkers know how to recognize and treat severe hypoglycemia.
- Continuous Glucose Monitoring (CGM): Consider using a CGM device, which continuously tracks blood glucose levels and alerts you to trends and potential hypoglycemic events.
Long-Term Prevention Strategies for Avoiding Severe Hypoglycemia
Preventing severe hypoglycemia requires a comprehensive and ongoing approach. It involves not only immediate management but also implementing long-term strategies.
-
Work Closely with Your Healthcare Team: Regular consultations with your endocrinologist, diabetes educator, and other healthcare professionals are vital. They can provide personalized advice on medication adjustments, diet, and exercise.
-
Develop a Hypoglycemia Action Plan: Create a written plan with your healthcare provider detailing how to manage hypoglycemia, including when to use glucagon and when to seek emergency medical help. Share this plan with family members and caregivers. Managing Type 1 Diabetes A Guide To Insulin And Glucose Levels
-
Consider Continuous Glucose Monitoring (CGM): CGM devices provide real-time glucose readings and can alert you to impending hypoglycemic events before they become severe. Many CGMs can be integrated with insulin pumps for automated insulin adjustments.
| CGM Feature | Benefit | | ----------------------------- | --------------------------------------------------------------- | | Real-time Glucose Readings | Allows for proactive management and immediate adjustments | | Trend Arrows | Indicates the direction and rate of glucose change | | Customizable Alerts | Warns of impending high or low glucose levels | | Data Tracking and Reporting | Provides insights for long-term glucose management adjustments | Proven Ways To Manage Blood Sugar Levels Naturally
-
Structured Education Programs: Participate in structured diabetes education programs that focus on hypoglycemia prevention and management. These programs can provide you with the knowledge and skills needed to effectively manage your diabetes.
-
Medication Review: Regularly review all your medications with your healthcare provider, as some medications can increase the risk of hypoglycemia. Adjustments to medication regimens may be necessary.
-
Alcohol Awareness: Be aware of the risks of alcohol consumption and hypoglycemia. If you choose to drink, do so in moderation and always with food.
-
Exercise Planning: Plan your exercise routines carefully, adjusting insulin doses or increasing carbohydrate intake as needed. Monitor your blood glucose levels before, during, and after exercise.
-
Psychological Support: Living with diabetes can be emotionally challenging, and fear of hypoglycemia can be a significant source of stress. Consider seeking psychological support or joining a support group to cope with these challenges.
Conclusion
Severe hypoglycemia is a serious and potentially life-threatening condition that requires prompt recognition and treatment. For people with diabetes, understanding the emergency signs, knowing how to administer glucagon, and implementing long-term prevention strategies are essential. By working closely with your healthcare team, educating your loved ones, and adopting a proactive approach to diabetes management, you can significantly reduce the risk of severe hypoglycemia and improve your overall quality of life. Always remember to seek immediate medical attention in the event of severe hypoglycemia, even after initial treatment with glucagon.
References and Further Reading
- blood sugar levels demystified from normal to diabetes ranges 9FWW9E
- best foods to control blood sugar amp manage hyperglycemia hY6vJG
- how to read your blood glucose levels a guide to mg dl and mmol l C1PpTn
- is your a1c high use our a1c to blood sugar conversion calculator xeXIgS
- best foods to control blood sugar amp manage hyperglycemia hHEIbd