A Guide to Severe Hypoglycemia: What to Do in an Emergency
05 Sep 2025 Aditi Kumar, M.B.B.S.
A Guide to Severe Hypoglycemia: What to Do in an Emergency
Severe hypoglycemia, or very low blood sugar, is a dangerous condition that can occur in individuals with diabetes, particularly those who take insulin or certain oral medications. Recognizing the signs, understanding the risks, and knowing how to respond swiftly and effectively are critical for preventing serious complications and ensuring the safety of the affected person. This guide aims to provide a comprehensive understanding of severe hypoglycemia, including how to identify it, what immediate steps to take, and the importance of follow-up care.
Understanding Hypoglycemia and Its Severity
Hypoglycemia occurs when the glucose level in the blood drops too low. For individuals with diabetes, this can happen due to a variety of factors, including missing meals, taking too much insulin, engaging in unexpected or strenuous physical activity, or consuming alcohol. While mild to moderate hypoglycemia can often be managed with quick-acting carbohydrates, severe hypoglycemia represents a more critical situation where the person is unable to treat themselves due to confusion, unconsciousness, or seizures.
Normal Blood Sugar Ranges: * Before meals: 70-130 mg/dL * After meals (1-2 hours): Less than 180 mg/dL
Hypoglycemia Levels: * Mild Hypoglycemia: Blood sugar below 70 mg/dL (but above 54 mg/dL). Symptoms can often be managed independently. * Moderate Hypoglycemia: Blood sugar between 54-70 mg/dL. Increased difficulty concentrating, irritability. May need assistance from another person. * Severe Hypoglycemia: Blood sugar below 54 mg/dL, or any hypoglycemic episode requiring assistance from another person due to altered mental status (confusion, loss of consciousness, seizure). A Step By Step Guide To An Accurate At Home Blood Sugar Test
Recognizing the Signs and Symptoms of Severe Hypoglycemia
Being able to recognize the signs and symptoms of severe hypoglycemia is crucial. These symptoms can vary from person to person, but they often include:
- Confusion or disorientation: Difficulty thinking clearly or responding appropriately.
- Loss of consciousness: Unresponsiveness to verbal or physical stimuli.
- Seizures: Uncontrolled muscle spasms or convulsions.
- Inability to swallow or cooperate with oral treatment: Individual cannot safely eat or drink.
Other symptoms that might precede the more severe manifestations include:
- Weakness or fatigue: Feeling unusually tired or lacking energy.
- Sweating: Profuse perspiration, even in a cool environment.
- Tremors: Shaking or trembling, especially in the hands.
- Rapid heart rate: A noticeably fast or irregular heartbeat.
- Blurred vision: Difficulty seeing clearly.
- Headache: A persistent or severe headache.
- Hunger: An overwhelming urge to eat.
- Anxiety or irritability: Feeling nervous, restless, or easily agitated.
It's important to remember that not everyone experiences all of these symptoms, and some individuals may develop hypoglycemia unawareness, where they don't feel the early warning signs of low blood sugar. This makes having a plan and readily available treatment even more vital. Can You Control Blood Glucose Levels With A Diabetic Diet Alone
Immediate Actions to Take During a Severe Hypoglycemic Episode
When someone is experiencing severe hypoglycemia, immediate action is necessary to prevent potentially life-threatening consequences. Here’s a step-by-step guide:
- Assess the Situation: Quickly determine if the person is conscious and able to swallow.
- If Conscious and Able to Swallow:
- Administer a fast-acting source of glucose, such as:
- Glucose gel or tablets: These are specifically designed to raise blood sugar quickly. Follow the product instructions for dosage (usually 15-20 grams).
- Juice or regular soda: Provide about 4 ounces (120 ml) of fruit juice or regular (non-diet) soda.
- Hard candies: Offer several hard candies to suck on (avoid chocolate, as the fat content can slow absorption).
- Check blood sugar after 15 minutes. If it's still low (below 70 mg/dL), repeat the glucose administration.
- Once blood sugar is above 70 mg/dL and the person is feeling better, provide a longer-acting source of carbohydrates, such as a sandwich or crackers with peanut butter, to help stabilize blood sugar levels.
- Administer a fast-acting source of glucose, such as:
- If Unconscious or Unable to Swallow:
- Administer Glucagon: If available, administer glucagon. Glucagon is a hormone that stimulates the liver to release stored glucose into the bloodstream. It's available as an injectable or nasal spray.
- Injectable Glucagon: Mix and inject according to the manufacturer’s instructions. Typically, adults and children over 25 kg (55 lbs) receive 1 mg, while children under 25 kg receive 0.5 mg. Inject into the thigh, arm, or buttock.
- Nasal Glucagon: Administer one spray into one nostril. No need to inhale.
- Call for Emergency Medical Assistance (911): Even if the person regains consciousness after glucagon administration, it is crucial to seek immediate medical attention.
- Administer Glucagon: If available, administer glucagon. Glucagon is a hormone that stimulates the liver to release stored glucose into the bloodstream. It's available as an injectable or nasal spray.
Important Notes:
- Do not attempt to give food or liquid to an unconscious person, as it could cause choking.
- Always have glucagon readily available if you or someone you know is at risk for severe hypoglycemia. Ensure that family members, friends, and caregivers know how to administer it. Check the expiration date regularly and replace as needed.
- Time is of the essence. The longer someone remains in a severely hypoglycemic state, the greater the risk of serious complications, including brain damage and death.
Glucagon: A Life-Saving Treatment for Severe Hypoglycemia
Glucagon is a synthetic hormone that raises blood glucose levels by stimulating the liver to release stored glucose. It is available by prescription and is essential for individuals at risk of severe hypoglycemia to have on hand. Glucagon kits typically include a vial of powdered glucagon and a syringe with sterile diluent. Newer formulations include nasal sprays, which are easier to administer.
How to Use Injectable Glucagon:
- Prepare the Glucagon: Remove the caps from the vial of glucagon powder and the syringe of diluent.
- Mix the Solution: Inject the diluent into the vial of glucagon powder. Gently roll or swirl the vial (do not shake) until the powder is completely dissolved.
- Draw Up the Solution: Using the same syringe, draw up the reconstituted glucagon solution.
- Administer the Injection: Inject the glucagon into the person’s upper arm, thigh, or buttock. Hold the syringe in place for a few seconds to ensure the full dose is delivered.
How to Use Nasal Glucagon:
- Remove the device from packaging.
- Hold the device between your fingers and thumb.
- Insert the tip fully into one nostril, and press the plunger firmly to release the dose.
- No need to inhale.
Important Considerations:
- Glucagon may cause nausea and vomiting upon recovery. Turn the person on their side to prevent choking.
- Glucagon's effects are temporary. Once the person regains consciousness and can swallow, give them a longer-acting source of carbohydrates.
- Glucagon is not a substitute for emergency medical care. Always call 911 after administering glucagon.
Prevention Strategies to Minimize the Risk of Severe Hypoglycemia
While knowing how to respond to severe hypoglycemia is vital, prevention is even more critical. Effective prevention strategies include:
- Regular Blood Glucose Monitoring: Consistently check blood sugar levels, especially before meals, before bedtime, and before and after exercise. Use a continuous glucose monitor (CGM) if recommended by your healthcare provider.
- Adhering to a Consistent Meal Schedule: Avoid skipping meals or delaying eating. Plan meals and snacks at regular intervals throughout the day.
- Careful Medication Management: Work closely with your healthcare provider to adjust insulin or other diabetes medication dosages based on your individual needs and lifestyle. Be aware of how different medications interact and affect blood sugar levels.
- Carbohydrate Counting: Learn how to accurately estimate the carbohydrate content of foods and adjust insulin dosages accordingly.
- Exercise Planning: Monitor blood sugar levels before, during, and after physical activity. Adjust insulin dosages or consume extra carbohydrates as needed to prevent hypoglycemia.
- Alcohol Consumption Awareness: Be cautious when consuming alcohol, as it can lower blood sugar levels, especially when combined with diabetes medications. Always eat food when drinking alcohol.
- Hypoglycemia Unawareness Training: If you experience hypoglycemia unawareness, consider training programs or techniques to help you recognize early warning signs.
Here’s a table summarizing these strategies:
| Strategy | Description | Benefits | | ------------------------------ | --------------------------------------------------------------------------------------------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------- | | Regular Blood Glucose Monitoring | Checking blood sugar levels multiple times a day. Use a CGM if appropriate | Early detection of blood sugar fluctuations, enabling timely intervention | | Consistent Meal Schedule | Eating meals and snacks at regular intervals | Prevents blood sugar from dropping too low due to prolonged periods without food | | Careful Medication Management | Adjusting insulin or other diabetes medication dosages as needed | Maintains stable blood sugar levels by ensuring the right amount of medication is taken at the right time | | Carbohydrate Counting | Estimating carbohydrate content of foods and adjusting insulin dosages accordingly | Helps balance insulin doses with carbohydrate intake, preventing significant blood sugar swings | | Exercise Planning | Monitoring blood sugar levels before, during, and after physical activity and adjusting insulin or carbohydrate intake as needed. | Prevents exercise-induced hypoglycemia by providing extra glucose or reducing insulin before physical activity | | Alcohol Consumption Awareness | Being cautious when consuming alcohol and always eating food | Reduces the risk of alcohol-induced hypoglycemia by slowing down alcohol absorption and maintaining glucose levels| | Hypoglycemia Unawareness Training | Techniques to help recognize early warning signs | Enables timely treatment of hypoglycemia and reduces the risk of severe episodes |
The Importance of Follow-Up Care and Education
After a severe hypoglycemic episode, it’s critical to follow up with a healthcare provider to review diabetes management and identify potential causes. This may involve adjusting medication dosages, refining meal plans, or exploring strategies to improve blood sugar control. Simple Steps To Lower Your Fasting Blood Glucose
Key Aspects of Follow-Up Care:
- Medical Evaluation: A thorough review of the hypoglycemic event, including contributing factors, symptoms, and treatment provided.
- Medication Adjustment: Evaluation and adjustment of insulin or other diabetes medications to reduce the risk of future episodes.
- Diabetes Education: Reinforcement of diabetes self-management skills, including blood glucose monitoring, carbohydrate counting, insulin administration, and hypoglycemia recognition and treatment.
- Psychological Support: Addressing any emotional or psychological impact of the hypoglycemic event, such as anxiety or fear of future episodes.
Communicating with Your Healthcare Team

Maintaining open and consistent communication with your healthcare team is essential for effective diabetes management. Be sure to report any instances of hypoglycemia, especially severe episodes, and discuss any challenges you are experiencing in managing your blood sugar levels.
References and Further Reading
- blood sugar friendly meals you can actually get excited about Z9orw5
- how to manage blood sugar spikes after meals postprandial guide u1ZP3c
- how to read a blood glucose meter from mg dl to mmol l zycSZe
- beyond diet 8 lifestyle hacks to control your blood sugar naturally 4kWMMG
- decoding your blood test a1c vs fasting glucose explained hrqbPk