Dr. Vikas Dutt

About

Dr. Vikas Dutt, Ph.D. (Biotechnology) from Kurukshetra University, currently working as Assistant Professor in Department of Life Sciences, Sharda School of Bio-Science & Technology (SSBT), Sharda University. He has qualified GATE-Biotechnology (2011 and 2012). During his Ph.D., he has worked on regulation of skeletal muscle mass under atrophic conditions induced by inflammation (TNFα) and oxidative stress (H2O2). He has gained vast experience in delineating the therapeutic potential of natural plant-based compounds on muscle atrophy conditions using in vitro (C2C12 myotubes) and in vivo (Albino mice) models. He is well versed with various techniques like microscopy (Fluorescence), molecular biology (SDS-PAGE, Western Blotting, qRT-PCR), tissue sectioning (cryo-sectioning), cell culture, animal handling and metabolomics. He has published more than 8 international publications related to this work.

Experience

• 2 year research, 2.5 year Teaching

Qualification

• B.Sc. Biochemistry
• M.Sc. Biotechnology
• Ph.D. Biotechnology

Award & Recognition

• GATE Biotechnology 2011
• GATE Biotechnology 2012

Research

Total Research - 7 research papers (all International)

Total Books - 3 book chapters (2 international)

• Dutt V, Kaur N, Sharma O, and Mittal A. Protective Effect of Butylated Hydroxytoluene on the Hydrogen Peroxide-Induced Skeletal Muscle Atrophy in Cultured Myotubes. Biochemistry (Moscow) (2025), 90 (10):1-12.
• Kaur N, Gupta P, Dutt V, Sharma O, Gupta S, Dua A, Injeti E, Mittal A. Cinnamaldehyde attenuates TNF-α induced skeletal muscle loss in C2C12 myotubes via regulation of protein synthesis, proteolysis, oxidative stress and inflammation. Archives of Biochemistry and Biophysics. (2024), 753:109922.
• Dutt V, Gupta P, Kaur N, Kalra P, Gupta S, Dua A, Dabur R, Saini V, Mittal A. S-allyl Cysteine: A Potential Compound Against Skeletal Muscle Atrophy. Biochimica et Biophysica Acta: General Subjects. (2020), 1864:129676.
• Sharma B, Dutt V, Kaur N, Mittal A, Dabur R. Tinospora cordifolia protects from skeletal muscle atrophy by alleviating oxidative stress and inflammation induced by sciatic denervation. Journal of Ethnopharmacology. (2020) 27;254:112720.
• Dutt V, Saini V, Gupta P, Kaur N, Bala M, Gujar R, Grewal A, Gupta S, Dua A, Mittal A. S-allyl cysteine inhibits TNFα-induced skeletal muscle wasting through suppressing proteolysis and expression of inflammatory molecules. Biochimica et Biophysica Acta: General Subjects. (2018), 1862(4):895-906.
• Dutt V, Kaur N, Gupta P, Gujar R, Grewal A, Gupta S, Dua A, Mittal A. Efficient and modified protocol for zymography to detect muscle specific calpain activity. Biocatalysis and Agricultural Biotechnology. (2017) 10:96–103.
• Dutt V, Gupta S, Dabur R, Injeti E, Mittal A. Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action. Pharmacological Research. (2015) 99:86-100.

Book Chapter

• Singh J, Singh V, Jakhad M.L, Dutt V, Shekhawat P.K, Suthar M.K, & Bagaria P.K. (2023). Stress Protectants in Amelioration of Abiotic Stress: Mechanism of Action and Potential Role in Sustaining Oilseed and Pulses Productivity. In: Kumar, A., Dhansu, P., Mann, A. (eds) Salinity and Drought Tolerance in Plants. Springer, Singapore.
• Lakhani, I., Dhiman, P., Dutt, V., Alim, H., Ali, A., Patel, N. (2025). Nanosensors for Detection of Agricultural Soil Microbes. In: Husen, A. (eds) Nanobiosensors for Agricultural and Other Related Sectors. Smart Nanomaterials Technology. Springer, Singapore.

Area of Interest

• Translational medicine and their application
• Stem cell research
• Oxidative stress and Inflammation
• Skeletal muscle atrophy and hypertrophy
• Plant bioactive components and their therapeutic applications on muscle atrophy