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Dr. Niraj Kumar Jha

Assistant Professor, Biotechnology

niraj.jha@sharda.ac.in

About

Dr. Jha has completed his master's degree in Biotechnology from Vellore Institute of Technology, Vellore, India and PhD from Delhi Technological University (Formerly Delhi College of Engineering), New Delhi, India. He has published more than fifteen scientific articles in peer-reviewed International journals, two chapters in International books and authored two novels. He holds membership of several international societies in Neurochemistry, and has received a number of awards and fellowships in the domain of life science research. He has also delivered several scientific talks at National platforms. He has expertise in the field of Neuro-informatics, Alzheimers disease, Cerebral Infarction/Ischemic Stroke, Drug screening and characterization.

Experience
  • 2 Year (teaching)+ 6 Year (research)
Qualification
  • Ph.D in Biotechnology (Delhi Technological University)
  • M.Sc. in Biotechnology (Vellore Institute of Technology)
Award & Recognition

  • Guest Editor Special Issue on "Role of Natural Antioxidants in Free Radical Biology and Human Health"(Antioxidants-MDPI)
  • Book Editor “Free Radical Biology and Environmental Toxicity” SPRINGER-Nature Switzerland AG
  • DBT Junior Research Fellowship (DBT-JRF)
  • DBT Senior Research Fellowship (DBT-SRF)
  • Technical Education Quality Improvement Programme (TEQIP) Fellowship
  • "Commendable Research Award" presented for excellence in research during the year 2017 at Delhi Technological University

Research

2020

  • Jha NK. Viral pathogenesis of SARS-CoV-2 infection and male reproductive health. Open Biol. 2020 (Article in press)
  • Jha NK. Molecular exploration of combinational therapy of orlistat with metformin prevent the COVID-19 consequences in obese diabetic patients. European Review for Medical and Pharmacological Sciences (Verduci Editore) 2020 (Article in press)
  • M.F.N. Meeran, Seenipandi Arunachalam, Hayate Javed, Charu Sharma, Hebaallah Mamdouh Hashiesh, Sameer N. Goyal, Niraj Kumar Jha, Shreesh Ojha, Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19?, Heliyon, 2020,e05703,ISSN 2405-8440,https://doi.org/10.1016/j.heliyon.2020.e05703.
  • Jha NK. Targeting eosinophils in respiratory diseases: biological axis, emerging therapeutics and treatment modalities. Life Sci. 2020 (Article in press)
  • Shukla SD, Shastri MD, Jha NK, Dua K. Microbial determinants of arthritis. EXCLI J. 2020 Dec 9;19:1549-1551. doi: 10.17179/excli2020-3180. PMID: 33343273; PMCID: PMC7744962.
  • Satyam R, Bhardwaj T, Goel S, Jha NK, Jha SK, Nand P, Ruokolainen J, Kamal MA, Kesari KK. miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis. Curr Pharm Des. 2020 Oct 1. doi: 10.2174/1381612826999201001200529. Epub ahead of print. PMID: 33023438.
  • Satyam R, Jha NK, Kar R, Jha SK, Sharma A, Kumar D, Nand P, Ruokolainen J, Kesari KK, Kamal MA. Deciphering the SSR incidences across viral members of Coronaviridae family. Chem Biol Interact. 2020 Nov 1;331:109226. doi: 10.1016/j.cbi.2020.109226. Epub 2020 Sep 21. PMID: 32971122; PMCID: PMC7505113.
  • Satyam R, Bhardwaj T, Jha NK, Jha SK, Nand P. Toward a chimeric vaccine against multiple isolates of Mycobacteroides - An integrative approach. Life Sci. 2020 Jun 1;250:117541. doi: 10.1016/j.lfs.2020.117541. Epub 2020 Mar 10. PMID: 32169520.
  • Kumar N, Sood D, Gupta A, Jha NK, Jain P, Chandra R. Cytotoxic T-lymphocyte elicited therapeutic vaccine candidate targeting cancer against MAGE-A11 carcinogenic protein. Biosci Rep. 2020 Dec 23;40(12):BSR20202349. doi: 10.1042/BSR20202349. PMID: 33169789; PMCID: PMC7711063.
  • Meeran MFN, Azimullah S, Al Ahbabi MM, Jha NK, Lakshmanan VK, Goyal SN, Ojha S. Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study. Molecules. 2020 Nov 30;25(23):5656. doi: 10.3390/molecules25235656. PMID: 33266249; PMCID: PMC7730250.
  • Javed H, Meeran MFN, Azimullah S, Bader Eddin L, Dwivedi VD, Jha NK, Ojha S. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. 2020 Oct 8;10(10):1421. doi: 10.3390/biom10101421. PMID: 33049992; PMCID: PMC7599960.
  • Jha NK, Sharma A, Jha SK, Ojha S, Chellappan DK, Gupta G, Kesari KK, Bhardwaj S, Shukla SD, Tambuwala MM, Ruokolainen J, Dua K, Singh SK. Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies. Open Biol. 2020 Dec;10(12):200286. doi: 10.1098/rsob.200286. Epub 2020 Dec 23. PMID: 33352062.
  • Sharma A, Jha NK, Dahiya K, Singh VK, Chaurasiya K, Jha AN, Jha SK, Mishra PC, Dholpuria S, Astya R, Nand P, Kumar A, Ruokolainen J, Kesari KK. Nanoparticulate RNA delivery systems in cancer. Cancer Rep (Hoboken). 2020 Oct;3(5):e1271. doi: 10.1002/cnr2.1271. Epub 2020 Jul 30. PMID: 32729987.
  • Tan YY, Yap PK, Xin Lim GL, Mehta M, Chan Y, Ng SW, Kapoor DN, Negi P, Anand K, Singh SK, Jha NK, Lim LC, Madheswaran T, Satija S, Gupta G, Dua K, Chellappan DK. Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics. Chem Biol Interact. 2020 Sep 25;329:109221. doi: 10.1016/j.cbi.2020.109221. Epub 2020 Aug 6. PMID: 32768398.
  • Jeyaraman M, John A, Koshy S, Ranjan R, Anudeep TC, Jain R, Swati K, Jha NK, Sharma A, Kesari KK, Prakash A, Nand P, Jha SK, Reddy PH. Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19. Biochim Biophys Acta Mol Basis Dis. 2020 Nov 22;1867(2):166014. doi: 10.1016/j.bbadis.2020.166014. Epub ahead of print. PMID: 33232817; PMCID: PMC7680525.
  • Khan F, Pandey P, Upadhyay TK, Jafri A, Jha NK, Mishra R, Singh V. Anti- Cancerous Effect of Rutin Against HPV-C33A Cervical Cancer Cells via G0/G1 Cell Cycle Arrest and Apoptotic Induction. Endocr Metab Immune Disord Drug Targets. 2020;20(3):409-418. doi: 10.2174/1871530319666190806122257. PMID: 31385777.

2019

  • Kar R, Jha NK, Jha SK, Sharma A, Dholpuria S, Asthana N, Chaurasiya K, Singh VK, Burgee S, Nand P. A "NOTCH" Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer. Genes (Basel). 2019 Nov 22;10(12):961. doi: 10.3390/genes10120961. PMID: 31766724; PMCID: PMC6947643.
  • Jha NK, Jha SK, Kar R, Nand P, Swati K, Goswami VK. Nuclear factor-kappa β as a therapeutic target for Alzheimer's disease. J Neurochem. 2019 Jul;150(2):113-137. doi: 10.1111/jnc.14687. Epub 2019 Mar 26. PMID: 30802950.
  • Jha NK, Kar R, Niranjan R. ABC Transporters in Neurological Disorders: An Important Gateway for Botanical Compounds Mediated Neuro-Therapeutics. Curr Top Med Chem. 2019;19(10):795-811. doi: 10.2174/1568026619666190412121811. PMID: 30977450.
  • Singh K, Jha NK, Thakur A. Spatiotemporal chromatin dynamics - A telltale of circadian epigenetic gene regulation. Life Sci. 2019 Mar 15;221:377-391. doi: 10.1016/j.lfs.2019.02.006. Epub 2019 Feb 2. PMID: 30721705.

2018

  • Jha NK, Jha SK, Sharma R, Kumar D, Ambasta RK, Kumar P. Hypoxia-Induced Signaling Activation in Neurodegenerative Diseases: Targets for New Therapeutic Strategies. J Alzheimers Dis. 2018;62(1):15-38. doi: 10.3233/JAD-170589. PMID:29439330.

2017

  • Jha SK, Jha NK, Kumar D, Sharma R, Shrivastava A, Ambasta RK, Kumar P.Stress-Induced Synaptic Dysfunction and Neurotransmitter Release in Alzheimer's Disease: Can Neurotransmitters and Neuromodulators be Potential Therapeutic Targets? J Alzheimers Dis. 2017;57(4):1017-1039. doi: 10.3233/JAD-160623. PMID:27662312.
  • Sharma R, Kumar D, Jha NK, Jha SK, Ambasta RK, Kumar P. Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die? Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):324-336. doi: 10.1016/j.bbadis.2016.09.010. Epub 2016 Sep 14. PMID: 27639832.
  • Jha SK, Jha NK, Kumar D, Ambasta RK, Kumar P. Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration.Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1132-1146. doi:10.1016/j.bbadis.2016.06.015. Epub 2016 Jun 21. PMID: 27345267.

2016

  • Kumar P, Kumar D, Jha SK, Jha NK, Ambasta RK. Ion Channels in Neurological Disorders. Adv Protein Chem Struct Biol. 2016;103:97-136. doi: 10.1016/bs.apcsb.2015.10.006. Epub 2015 Nov 28. PMID: 26920688.

2015

  • Jha SK, Jha NK, Kar R, Ambasta RK, Kumar P. p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's Disease. Int J Mol Cell Med. 2015 Spring;4(2):67-86. PMID: 26261796; PMCID: PMC4499569.
  • Jha NK, Jha SK, Kumar D, Kejriwal N, Sharma R, Ambasta RK, Kumar P. Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications. J Alzheimers Dis. 2015;48(4):891-917. doi: 10.3233/JAD-150379. PMID: 26444774.
  • 27: Kumar P, Jha NK, Jha SK, Ramani K, Ambasta RK. Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimer's disease. J Alzheimers Dis. 2015;43(2):341-61. doi: 10.3233/JAD-140933. PMID: 25096626.
  • 28: Ambasta RK, Jha SK, Kumar D, Sharma R, Jha NK, Kumar P. Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules. J Transl Med. 2015 Sep 18;13:307. doi: 10.1186/s12967-015-0665-z. PMID: 26385094; PMCID: PMC4575424.

2014

  • Jha NK, Kar R, Ambasta RK and Kumar P, (2014), Role of oxidative stress, ER stress and Ubiquitin Proteasome system in neurodegeneration, MOJ Cell Science and Report, 01(2)

Book Chapters

  • Jha S.K. et al. (2020) Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism. In: Kumar D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore
  • Jha N.K. et al. (2020) Clinical Relevance of “Biomarkers” in Cancer Metabolism. In: Kumar D. (eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy. Springer, Singapore
  • Jha N.K. et al. (2016) Epigenetics and Angiogenesis in Cancer. In: Mishra M., Bishnupuri K. (eds) Epigenetic Advancements in Cancer. Springer, Cham

Area of Interest

  • Natural Products
  • Cell Signaling and Disease