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Dr. Vivek Srivastava

Assistant Professor, Chemistry and Biochemistry

vivek.srivastava1@sharda.ac.in

About

I have more than two years of teaching experience in Biochemistry at Sharda University. This is my first teaching career in Sharda family.  I had been trained with Dr. Sagar Sengupta at the National Institute of Immunology for my doctorate, where I studied the role of BLM helicases in DNA damage signal transduction pathway and as a Postdoctoral Research Fellow, I was associated with Dr. Shantanu Chowdhury at CSIR-Institute of Genomics and Integrative Biology, where I studied how a small protein NME2 engages a relatively huge protein-RNA complex telomerase in cancer cells. My work had started putting a framework together to understand mechanisms of metastasis suppression that involve NME2-telomerase interactions. I patiently introduced 'beginners' to the nuances of protein biochemistry, telomerase function and phosphoprotein signaling. My interests include post-translational modifications of proteins, cancer biology and DNA damage response.

 

 

Experience
  • More than two years of teaching experience. Subjects taught/currently teaching Molecular Biology, Recombinant DNA technology, Biomolecules, Metabolism, Cell Biology, Plant Biochemistry, Human Physiology, Nutritional Biochemistry, Human Health and Diseases.   
  • 2. Nine years of research experience.
Qualification
  • Ph.D. in Biotechnology
Award & Recognition

  • Awarded for oral presentation at National Conference organized by Department of Biotechnology, Sharda University.
  • Received reward for publishing research paper from Sharda University.

Research

  • Mukherjee AK, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T1, Srivastava V, Roy SD, Shay JW4 Chowdhury S. Plos Genetics. 2018 Nov 15;14(11) e1007782. doi 10.1371/journal.pgen.1007782. Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends. (Impact factor 5.54)
  • Saha D, Singh A, Hussain T, Srivastava V, Sengupta S, Kar A, Dhapola P, Dhople V, Ummanni R, Chowdhury S. J Biol Chem. 2017 Sep 15;292(37)15205-15215. doi 10.1074/jbc.M117.792077. Epub,2017, Jul17. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. (Impact factor 4.2)
  • Kharat SS, Tripathi V, Damodaran AP, Priyadarshini R, Chandra S, Tikoo S, Nandhakumar R, Srivastava V, Priya S, Hussain M, Kaur S, Fishman JB, Sengupta S. Oncogene. 2015 Jun 1. doi 10.1038/onc.2015.157. Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. (Impact factor 7.9)
  • Gupta S, De S, Srivastava V, Hussain M, Kumari J, Muniyappa K, Sengupta S. Carcinogenesis. 2014 Jan; 35(1)34-45. RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome (Impact factor 5.4)
  • Chandra S, Priyadarshini R, Madhavan V, Tikoo S, Hussain M, Mudgal R, Modi P, Srivastava V, Sengupta S. Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation. Journal of Cell Science. 2013 Aug 15; 126(Pt 16)3782-95. (Impact factor 5.5)
  • Kaur S*, Modi P*, Srivastava V*, Mudgal R*, Tikoo S, Arora P, Mohanty D, Sengupta S (2010). Chk1-dependent constitutive phosphorylation of BLM helicase at Serine 646 decreases after DNA damage. Molecular Cancer Research. 81234-1247 (* signifies equal first authors). (Impact factor 4.1)
  • Srivastava V, Modi P, Tripathi V, Mudgal R, De S, Sengupta S (2009). BLM helicase stimulates the ATPase and chromatin remodeling activities of RAD54. Journal of Cell Science. 2009 122 3093-3103. (Impact factor 5.5)
  • Vivek Srivastava, Suman Sengupta, Shalu Sharma, Twinkle Khera, Shantanu Chowdhury. A mechanistic approach to elucidate NME2-mediated suppression of telomerase activity in cancer cells. (In communication)

Certifications

  1. 10 days certificate course from Bioinformatics Education Program, Bangalore.
  2. Certificate from International/ National conferences, workshop and symposium.

Area of Interest

  • Telomere Biology, Post-translational modifications of Protein, Role of Mitochondria in aging/ cancer, Epigenetics, DNA damage response pathway