Dr. Vivek Srivastava

About

Dr. Vivek Srivastava is an accomplished academician and researcher in the field of Biochemistry with over a decade of teaching and research experience. Currently serving as an Associate Professor at Sharda University, he has extensive expertise in molecular biology, cancer biology, and computational drug discovery. His research focuses on DNA damage response, protein biochemistry, epigenetics, and nanomaterials. He has successfully led funded research projects and contributed significantly to high-impact publications in reputed international journals. His interdisciplinary work integrates in silico and experimental approaches for therapeutic advancements.

Skill sets & Expertise

• Advanced Molecular Biology Techniques: Conventional PCR, RT-PCR, Gene Cloning & Site-Directed Mutagenesis
• Recombinant Protein Engineering: High-efficiency expression & purification using GST, His, and MBP tagging systems
• Protein–DNA Interaction & Epigenetic Analysis: EMSA, ChIP, Immunoprecipitation, Western & Southern Blotting
• Cellular & Cancer Biology Techniques: Mammalian cell culture, transfection strategies & stable cell line development
• Computational Drug Discovery: Molecular docking, in silico modeling & structure-based analysis
• Functional Biochemistry Assays: Kinase assay, Ubiquitination pathways & telomerase (TRAP) assays

Experience

• Associate Professor, Sharda University (2023–Present)
• Assistant Professor Grade-III (2022-2023)
• Assistant Professor Grade-I (2017–2021)
• Postdoctoral Fellow, CSIR-Institute of Genomics & Integrative Biology (2012–2016)
• Project Fellow, National Institute of Immunology (2006–2011)

Qualification

• M.Sc. (Biochemistry)
• Ph.D. (Biotechnology)

Award & Recognition

• Recipient of the Outstanding Researcher in Biochemistry Award at the Venus International Healthcare Awards (VIHA), 2021
• Best Teacher Award for outstanding contribution in the field of Biochemistry in 4^th National Annual Conference organized by the Department of Biotechnology & Microbiology, Kalp Laboratories, Mathura, July 2021.
• Awarded the prestigious TARE Fellowship by the DST-SERB, Government of India, for research excellence
• Recipient of Best Innovation Award and Best Researcher Award (2020) for significant scientific contributions
• Silver Honor Award by Bioconcurrence-2020 Global Meet held on 23rd -24th August 2020, organized by School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya (University of Technology, Govt. of Madhya Pradesh), Bhopal.
• Delivered Invited Talks and served as Session Chair at multiple reputed national and international conferences
• Winner of several Best Oral and Poster Presentation Awards at national and international scientific forums

Research

• Understanding the therapeutic potential of phytochemicals derived from Thuja occidentalis in Breast Cancer.
• Uncovering How Areca Nut Phytochemicals Drive Cancer: Insights from Integrated in Silico and in Vitro Studies

Publications:

• Sarkar, P., Guin, M., Srivastava, V*., Taneja, N.K., and Narayanan, S.S. (2026). Role of Green-Synthesized Silver and Copper Oxide Nanoparticles in Modulating DNA Topoisomerase III Activity and DNA Methyltransferase I Protein Expression Through In Vitro and In Silico Approaches. BioNanoScience, 16(2), p.131. (Q2, IF: 3.5)
• Rathore, M., Mallick, S., and Srivastava, V*. (2026). Assessing Stigmasterol's Antidiabetic Potential Through Molecular Docking and DFT Approach. Current Drug Therapy (Accepted, December 2025). (Q3, IF: 0.8)
• Biresaw, S.S., Sarkar, P., Taneja, P., Taneja, N.K., Srivastava, V., Lahiri, D., and Nag, M. (2026). Molecular Docking and Anticancerous Activity of Zinc Oxide Nanoparticles Synthesized from Fruits of Prunus nepalensis Extract. Biotechnology and Applied Biochemistry. (Q1, IF: 2.7)
• Tomar, S., Siddiqui, S., Pathak, R., and Srivastava, V*. (2025). Unlocking the Potential of Immunomodulators as Synergistic Immune-Based Therapies in Cancer. Discovery Medicine, 37(194), pp.411–432. (Q3, IF: 2.1)
• Mamman, A., Jain, P., and Srivastava, V. (2024). Exploring the Catalytic, Bactericidal, and Anticancer Potential of Ag⁰, Au⁰, and Ag⁰@Au⁰ Nanoparticles: A Comparative Study. Colloids and Surfaces A: Physicochemical and Engineering Aspects, p.135855. (Q1, IF: 4.9)
• Shahid, M., Jain, P., De, A., Srivastava, V., Singh, A., Garg, M., and Kamilya, S. (2024). Synthesis, Characterization, Crystal Structure, and Molecular Docking of o-Vanillin and L-Valine-Derived Molecules: A DFT Study and Antiproliferative Activity Against the PANC-1 Cancer Cell Line. New Journal of Chemistry. (Q2, IF: 2.7)
• Banerjee, B., Ali, A., Verma, R.K., Guin, M., Sharma, P., Chakravorty, T., et al. (2024). Synthesis and Structural Characterization of Phenoxo-Bridged Zinc (II) Complexes and Their Binding Interaction with the Spike Protein of SARS-CoV-2. Phosphorus, Sulfur, and Silicon and the Related Elements, pp.1–14. (Q2, IF: 1.7)
• Kaur, E., Agrawal, R., Arun, R., Madhavan, V., Srivastava, V., Kumar, D., Rath, P.P., Kumar, N., Vedagopuram, S., Pandey, N., and Priya, S. (2024). Small Molecules that Disrupt RAD54-BLM Interaction Hamper Tumor Proliferation in Colon Cancer Chemoresistance Models. The Journal of Clinical Investigation. (Q1, IF: 15.9)
• Ahmad, A., Tiwari, R.K., Siddiqui, S., Chadha, M., Shukla, R., and Srivastava, V*. (2024). Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in Carcinogenesis and Tumor Progression. International Review of Cell and Molecular Biology, 385, pp.41–99. (Q1, IF: 6.8)
• Tomar, R., Sarkar, P., Srivastava, V., Gupta, P., Malik, S., Khan, A.A., and Tambuwala, M. (2023). Exploring the Staphylococcus aureus Gyrase Complex and Human Topoisomerase: Potential Target for Molecular Docking and Biological Studies with Substituted Polychloroaniline. ACS Omega, 8(47), pp.44812–44819. (Q1, IF: 4.1)
• Sarkar, P., Niraj, N., and Srivastava, V*. (2023). In Silico Identification of Small Natural Inhibitors Against DNA Methyl Transferase 3-Like Protein by Integrative Molecular Docking and Molecular Dynamics Approach. Chemical Biology Letters, 10(2), pp.537–537. (Q1, IF: 2.3)
• Sarkar, P., Srivastava, V., and Guin, M. (2022). A Comparative Study Through DFT Investigation and Molecular Docking Studies of Potential Dietary Phytochemicals Against Cancer Target DNA Topoisomerase III. Physical Chemistry Research, 11(2), pp.391–408. (Q3, IF: 1.24)
• De, A., Jain, P., Manna, A.K., Srivastava, V., and Das, R. (2021). An Eco-Benign Synthesis of Silver Nanoparticles Using Aegle marmelos L. Bark Extract and Evaluation of Their DNA Cleavage, DNA Binding, Antioxidant, and Antibacterial Activity. Inorganic and Nano-Metal Chemistry, pp.1–12. (Q3, IF: 1.7)
• Yadav, A., Singh, S., Srivastava, V*., Bardhan, N., Gupta, S., Sarkar, P., and Kaur, H. (2021). A Review Article on Vaccine Development and Therapeutics Approach Against SARS-CoV-2. The Open COVID Journal
• Mukherjee, A.K., Sharma, S., Sengupta, S., Saha, D., Kumar, P., Hussain, T., Srivastava, V., Roy, S.D., Shay, J.W., and Chowdhury, S. (2018). Telomere Length-Dependent Transcription and Epigenetic Modifications in Promoters Remote from Telomere Ends. PLoS Genetics, 14(11), p.e1007782. (Q1, IF: 6.02)
• Saha, D., Singh, A., Hussain, T., Srivastava, V., Sengupta, S., Kar, A., Dhapola, P., Dhople, V., Ummanni, R., and Chowdhury, S. (2017). Epigenetic Suppression of Human Telomerase (hTERT) is Mediated by the Metastasis Suppressor NME2 in a G-Quadruplex–Dependent Fashion. Journal of Biological Chemistry, 292(37), pp.15205–15215. (Q1, IF: 5.4)
• Kharat, S.S., Tripathi, V., Damodaran, A.P., Priyadarshini, R., Chandra, S., Tikoo, S., Nandhakumar, R., Srivastava, V., Priya, S., and Hussain, M. (2016). Mitotic Phosphorylation of Bloom Helicase at Thr182 is Required for Its Proteasomal Degradation and Maintenance of Chromosomal Stability. Oncogene, 35(8), pp.1025–1038. (Q1, IF: 8.7)
• Gupta, S., De, S., Srivastava, V., Hussain, M., Kumari, J., Muniyappa, K., and Sengupta, S. (2014). RECQL4 and p53 Potentiate the Activity of Polymerase γ and Maintain the Integrity of the Human Mitochondrial Genome. Carcinogenesis, 35(1), pp.34–45. (Q1, IF: 5.4)
• Chandra, S., Priyadarshini, R., Madhavan, V., Tikoo, S., Hussain, M., Mudgal, R., Modi, P., Srivastava, V., and Sengupta, S. (2013). Enhancement of c-Myc Degradation by BLM Helicase Leads to Delayed Tumor Initiation. Journal of Cell Science, 126(16), pp.3782–3795. (Q1, IF: 5.2)
• Kaur, S., Modi, P., Srivastava, V$, Mudgal, R., Tikoo, S., Arora, P., Mohanty, D., and Sengupta, S. (2010). Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases After DNA Damage. Molecular Cancer Research, 8(9), pp.1234–1247. (Q1, IF: 6.3)
• Srivastava, V., Modi, P., Tripathi, V., Mudgal, R., De, S., and Sengupta, S. (2009). BLM Helicase Stimulates the ATPase and Chromatin-Remodeling Activities of RAD54. Journal of Cell Science, 122(17), pp.3093–3103. (Q1, IF: 5.2)

Book Chapters

• Srivastava, V., Siddiqui, S., Dhondiyal, A., Gupta, P. and Yadav, A., 2022. Telomerase and its Inhibitor in Cancer Therapeutics: Current Status and Future Prospective. In Natural Products as Enzyme Inhibitors (pp. 227-249). Springer, Singapore.
• Vivek Srivastava. Post-translational modification of Human telomerase in cancer cells: The Regulatory Machinery. 2021, Selective and Scientific Books, ISBN No 978-93-92787-16-4
• Paratpar Sarkar, Vivek Srivastava. Cancer Nanomedicines: Targeted drugs to overcome chemotherapeutic side effects. 2021, Selective and Scientific Books, ISBN No 978-93-92787-16-4

Patent Granted

• Anticancer Molecular Organic Framework Comprising Se/Te, N and O, their Metal Complexes and Preparations Thereof. Bhaskar Banerjee, Vinay K Verma, Vivek Srivastava and Ram Chandra Singh. Patent No: 202311008531, 2024.

Research Guidance

• Supervised 1 Research Associate
• Guided 1 Ph.D. scholar (awarded) and 2 Ph.D. scholars (ongoing)
• Mentored 25 Undergraduate (UG) and 5 Postgraduate (PG) Biochemistry student projects

Memberships

• Member, Royal Society of Biology (UK)
• Indian Science Congress Association
• Indian Association for Cancer Research
• Indian Society of Chemists and Biologists
• IANCAS (Indian Association of Nuclear Chemists & Allied Scientists)
• Society for Biotechnologists

Certifications

• Genome Editing & Engineering
• Computational Genomics
• Computational Drug Discovery
• Immunology
• Bioengineering: An Interface with Biology and Medicine
• Multiple FDPs, Workshops & International Conferences

Area of Interest

• Cancer Biology
• Protein Biochemistry
• DNA Damage Response Pathway
• Post-translational Modifications
• Mitochondrial Biology
• Drug Designing
• Nanomaterials