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Dr. Monika Jain

Assistant Professor, Biotechnology

monika.jain@sharda.ac.in

About

Ph.D. in Biotechnology, CSIR NET-LS, with outstanding academic track record including Dissertation from Indian Institute of Sciences (IISc), Bangalore. 17 years of teaching and 7 years of research experience in various reputed universities of India like Banasthali University, Jaipur National University and Sharda University (currently working as Assistant Professor in department of Biotechnology, School of Engineering & Technology). Published over 19 research papers in peer reviewed journals, Authored two Text Books (Environmental Biotechnology and Recombinant DNA Techniques). Completed 6 MOOCs from various reputed universities like MIT, USA, Purdue University, USA and Tel Aviv University, Israel. Taught subjects like Recombinant DNA Technology, Molecular Biology, Signal Transduction, Immunology, Cancer Biology, Biochemistry, Bioethics and IPR, Waste Management etc.

Experience
  • 17 Years
Qualification
  • Ph.D. in Biotechnology
  • CSIR-UGC-NET Life sciences
  • M Sc Biotechnology
  • Post Graduation Diploma in Intellectual Property Rights

 

Award & Recognition

  • CSIR NET (LS)

Research

Books:

  • Recombinant DNA Techniques-Narosa Publishing House Ltd.
  • Environmental Biotechnology- Narosa Publishing House Ltd.

Research Publications:

  • Jain M, Muthukumaran J, Singh AK. Structural and functional characterization of chitin binding lectin from Datura stramonium: insights from phylogenetic analysis, protein structure prediction, molecular docking and molecular dynamics simulation. J Biomol Struct Dyn. 2020 Mar 11:1-19. doi: 10.1080/07391102.2020.1737234. Epub ahead of print. PMID: 32116131.
  • Jain M, Muthukumaran J, Singh AK. Comparative structural and functional analysis of STL and SLL, chitin-binding lectins from Solanum spp. J Biomol Struct Dyn. 2020 Jun 22:1-16. doi: 10.1080/07391102.2020.1781693
  • Khan RJ, Jha RK, Amera GM, Jain M, Singh E, Pathak A, Singh RP, Muthukumaran J, Singh AK. Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2'-O-ribose methyltransferase. J Biomol Struct Dyn. 2020 Apr 20:1-14. doi: 10.1080/07391102.2020.1753577.
  • Sachithanandam V, Parthiban A, Lalitha P, Muthukumaran J, Jain M, Elumalai D, Jayabal K, Sridhar R, Ramachandran P, Ramachandran R. Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: insights from extensive in vitro and in silico studies. J Biomol Struct Dyn. 2020 Sep 30:1-13. doi: 10.1080/07391102.2020.1828173. 
  • Khan RJ, Jha RK, Singh E, Jain M, Amera GM, Singh RP, Muthukumaran J, Singh AK. Identification of promising antiviral drug candidates against non-structural protein 15 (NSP15) from SARS-CoV-2: an in silicoassisted drug-repurposing study. J Biomol Struct Dyn. 2020 Sep 4:1-11. doi: 10.1080/07391102.2020.1814870.
  • Amera GM, Khan RJ, Pathak A, Jha RK, Jain M, Muthukumaran J, Singh AK. Structure based drug designing and discovery of promising lead molecules against UDP-N-acetylenolpyruvoylglucosamine reductase (MurB): A potential drug target in multi-drug resistant Acinetobacter baumannii. J Mol Graph Model. 2020 Nov;100:107675. doi: 10.1016/j.jmgm.2020.107675.
  • Jha RK, Khan RJ, Amera GM, Singh E, Pathak A, Jain M, Muthukumaran J, Singh AK. Identification of promising molecules against MurD ligase from Acinetobacter baumannii: insights from comparative protein modelling, virtual screening, molecular dynamics simulations and MM/PBSA analysis. J Mol Model. 2020 Oct 17;26(11):304. doi: 10.1007/s00894-020-04557-4. PMID: 33068184.
  • Singh E, Khan RJ, Jha RK, Amera GM, Jain M, Singh RP, Muthukumaran J, Singh AK. A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods. J Genet Eng Biotechnol. 2020 Nov 3;18(1):69. doi: 10.1186/s43141-020-00085-z. PMID: 33141358; PMCID: PMC7607901.
  • V. Sachithanandam, P. Lalitha, A. Parthiban, Jayaraman Muthukumaran, Monika Jain, Ranjita Misra, T. Mageswaran, R. Sridhar, R. Purvaja & R. Ramesh (2021) A comprehensive in silico and in vitro studies on quinizarin: a promising phytochemical derived from Rhizophora mucronata Lam, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1894983.
  • Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Teresa Santos-Silva, Hamad A. Al-Lohedan, Noura Saad Al-Shuail, Molecular interactions of cefoperazone with bovine serum albumin: Extensive experimental and computational investigations, Journal of Molecular Liquids, Volume 337,2021,116354,ISSN 0167-7322, https://doi.org/10.1016/ j.molliq.2021.116354.
  • Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Hamad A. Al-Lohedan, M. Abul Farah & Osama Ibrahim Alsowilem (2021) Experimental and computational investigation on the binding of anticancer drug gemcitabine with bovine serum albumin, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1924270
  • Mohd. Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Abdullah Saad S. Al-Sanea, Hamad A. Al-Lohedan, Experimental and in silico investigation on the interaction of indomethacin with bovine serum albumin: Effect of sodium dodecyl sulfate surfactant monomers on the binding, Journal of Molecular Liquids, Volume336, 2021, 116858,ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2021.116858.
  • Khan RJ, Jha RK, Singh E, A. Parthiban, Jain M, E Singh, Amera GM, Ramachandran, Purvaja, Ramachandran, Ramesh, Singh RP, V, Sachithanandam, Muthukumaran J, Singh AK. Identifying the natural compound Catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-CoV-2: an integrated in silico approach. J Biomol Struct Dyn. 2021 Sep
  • Parthiban, A., Sachithanandam, V., Lalitha, P., Muthukumaran, J., Misra, R., Jain, M., Sridhar, R., Mageswaran, T., Purvaja, R., & Ramesh, R. (2021). Isolation, characterisation, anticancer and anti-oxidant activities of 2-methoxy mucic acid from Rhizophora apiculata: an in vitro and in silico studies. Journal of biomolecular structure & dynamics, 1–13. Advance online publication. https://doi.org/10.1080/07391102.2021.2020688
  • Sachithanandam, A. Parthiban, P. Lalitha, R. Nandini Asha, T. Christopher Jeyakumar, Jayaraman Muthukumaran, Jain Monika, T. Mageswarana, R.Sridhara, R. Purvajaa and R. Ramesha; Isolation and biological evaluation 7-hydroxy flavone from Avicennia Officinalis L: Insights from extensive in vitro, DFT, Molecular docking and Molecular dynamics simulation studies, J Biomol Struct Dyn. 2022
  • Jain, M., Amera, G., Muthukumaran, J. and Singh, A., 2022. Insights into biological role of plant defense proteins: A review. Biocatalysis and Agricultural Biotechnology, Volume 40, 102293, ISSN 1878-8181, https://doi.org/10.1016/j.bcab.2022.102293.
  • Rajat Kumar Jha, Rameez Jabeer Khan, Ekampreet Singh, Ankit Kumar, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh,An extensive computational study to identify potential inhibitors of Acyl-homoserine-lactone synthase from Acinetobacter baumannii (strain AYE), Journal of Molecular Graphics and Modelling,Volume 114,2022,108168,ISSN 1093-3263, https://doi.org/10.1016/j.jmgm.2022.108168.
  • Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, and Amit Kumar Singh. Ligand-Based Approaches for the Development of Drugs Against SARS-CoV-2; Methods in Pharmacology and Toxicology 2021/4/6.
  • Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, and Amit Kumar Singh. Computational Drug Repurposing for the Development of Drugs Against Coronaviruses; Methods in Pharmacology and Toxicology; 2021/4/6.

Certifications

FDPs attended/Organised

  • Orientation/Refresher Program on Use of ICT in Engineering Education (15 - 20 March 2021) - Sponsored by AICTE-ISTE, organized by Maharaja Surajmal Institute of Technology.
  • Intellectual Property Rights, Technology Transfer and Entrepreneurship (4 Jan - 9 Jan 2021) - organized by iTTO, IIT Delhi, in collaboration with Sharda University - Organizer and Participant of FDP.
  • Research Advances in Plant & Microbial Biotechnology (13 July - 18 July 2020) - organized by Department of Biotechnology, Jaypee Institute of information Technology, NOIDA.
  • Waste to Bioenergy (28 June - 4 July 2020) - organized by Dept. of Life Sciences, SBSR, Sharda University and Dept. of Agricultural Engineering, Maharashtra Institute of Technology, Aurangabad.
  • Outcome based education and Accreditation (25 May - 29 May 2020) - Organized by IILM Greater Noida.
  • Research Methodology: Tools And Technique (18 May - 22 May 2020) - Organized by IILM greater Noida.
  • Agriculture, Food Science and Environmental Dynamics: Integrating Technology, People and Sustainable Development (1 July - 5 July 2019) - Organized by IILM in co-ordination with Dr A P J Abdul Kalam Technical University, Lucknow.
  • How to Plan, Write and Submit Project Proposals (31 Jan 2019) - Organized by RTDC, Sharda University.
  • Approaches for In Silico Drug designing (3 July - 7 July 2018) - Organized by IILM in co-ordination with Dr A P J Abdul Kalam Technical University, Lucknow.

Best Conferences

  • Best Poster Presented in 48th National Seminar on Crystallography held on 25th- 27th Nov 2021 organized by Department of Biosciences and Bioengineering under the aegis of Indian Crystallographic Association (ICA) at Indian Institute of Technology, Roorkee.
  • Presented in National conference “Bridging the Gap: Between Basic and Clinical Research from Bench to Bed Side” held on 11th and 12th January 2018 at JLN Auditorium, All India Institute of Medical Sciences, New Delhi.
  • Presented in National Conference on Protein Structure and Dynamics in Health and Agriculture November 3-4, 2017, organized by: Department of Biosciences and Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, under the aegis of Protein Society, India.
  • Presented in IBEM 2017 (International Biological engineering meeting) at Jawahar Lal Nehru University, 26-28 March 2017.
  • Presented in, "Development and advancement in conservation, propagation and sustainable utilization of medicinal plants" on 20 and 21 Jan 2017 at GBU, Greater Noida.

 

MOOCs

  1. Biological Engineering Cellular Design Principles from Purdue University
  2. Molecular Biology –Transcription and Transposition" from MIT, USA
  3. Molecular Biology- RNA Processing and Translation" From MIT, USA
  4. Viruses & How to Beat Them Cells, Immunity, Vaccines, From Tel Aviv University, Israel
  5. Molecular Biology – DNA Replication and Repair" from MIT, USA
  6. CIC from IGNOU.
  7. 4 Week MOOC on Covid19-novel-coronavirus- London School    of Hygiene & Tropical Medicine and UK Public Health Rapid Support Team

Area of Interest

  • Protein structural Biology
  • Bioinformatics
  • Immunology
  • Molecular Biology
  • Proteomics
  • RDT