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Dr. Archana Pandita

Assistant Professor, Biotechnology

archana.pandit@sharda.ac.in

About

My work have demonstrated that dietary molecules and drug potentiate cytotoxicity across a range of clinically achievable doses, an inference drawn from the experiments with human pancreatic cancer cell lines. The clinical implications of this synergistic interaction are paramount and include improvements in efficacy, treatment-associated toxicity, tolerability of therapeutic regimens, and quality of life. Transfection with  microRNA along with the drug and dietary molecules  behaved differently in both the cancer cell lines and the mechanism of synergy involved the decrease in the expression of Pro caspase 3 and PARP followed by cleaved PARP, that signifies the apoptotic path. Worked on “Study of the synergistic effect of dietary molecules in combination with clinically validated cancer chemotherapeutic agents” at JNU, New Delhi as Doctorate fellow.

Experience
  • Research Experience more than 6 years and 1 year teaching experience
Qualification
  • Ph.D
Award & Recognition

  • “3rd International Conference on Stem Cells and Cancer (ICSCC-2012) Proliferation, Differentiation, and Apoptosis”. New Delhi, India.
  • Won Best Poster award at “4th International Conference on Stem Cells and Cancer (ICSCC-2013) Proliferation, Differentiation and Apoptosis”. Mumbai, India.
  • Poster presented in “5th International Conference on Translational Cancer Research”. New Delhi, India

Research

  • Archana Pandita, Bhupender Kumar, Siddharth Manvati, Samantha Vaishnavi, Shashank K. Singh*,Rameshwar N. K. Bamezai, Synergistic Combination of Gemcitabine and Dietary Molecule Induces Apoptosis in Pancreatic Cancer Cells and Down Regulates PKM2 Expression, PLoS ONE 9(9) e107154. doi10.1371/journal.pone.0107154 PMID 25197966 (IF 3.99)
  • Archana Pandita , Siddharth Manvati , Shashank K. Singh , Samantha Vaishnavi, Rameshwar N.K. Bamezai*, Combined effect of microRNA, nutraceuticals and drug on pancreatic cancer cell lines, Chemico-Biological Interactions 233 (2015) 56–64 PMID 25841339 (IF 2.98)

Area of Intrest

  • Cancer Therapeutic
  • Synergism
  • Drug Designing and development