Virology & Immunology

Research

SARS-CoV-2

We have undertaken In-Vitro studies to understand the pathogenesis of SARS-CoV-2 in alveoli.

Respiratory Viruses

Respiratory viruses including recently appeared Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)....

HCV - Hepatitis C virus

Hepatitis C virus infection is one of the main causes of liver disease that can lead to liver cirrhosis and finally...

EBV - Epstein-Barr virus

Epstein - Barr virus (EBV), is a herpesvirus. The virus is transmitted through saliva, and resides in the epithelial cells of the oral cavity.

Breast cancer

Work In Progress

Dengue virus

Dengue and its severe forms, the Dengue Haemorrhagic Fever and the Dengue Shock Syndrome have been a major health problem since the past many years.

Biosensors

Biosensor for HCV detection in patient samples coupled with double-noble nanoparticles on carbon ink-patterned paper electrode

Drug development

Molecular dynamics of Host receptor-Drug complex

Vaccine Research

The spike-protein or S protein, binds to the Receptor Binding Domain (RBD) of the receptor i.e. Angiotensin Converting Enzyme-2 (ACE-2) which is present on the host cell.

Vector Biology

Blood meal intake by Aedes mosquitoes: a simple new method for in vitro experimentations

Autoimmune diseases

Autoimmune

Plant product

Isolation of Larvicidal component(s) from Calotropis procera against Aedes mosquitoes.

Publications

Publications with Sharda affiliation (2021 onwards)

Singh S, Kumari K, Angel A, Angel B, Joshi V, Abdin MZ, Fatima S, Farooqi H, Narang J. 2026. Ultra-sensitive impedimetric biosensor for HCV detection in patient samples coupled with double-noble nanoparticles on carbon ink-patterned paper electrode. Microchimica Acta, 193:47
Chouhan R, Joshi V, Angel A, Angel B. 2025. Characterization of extrinsic and intrinsic forms of dengue virus – a cohort study. Journal of Entomology Research, DOI: 49 (4): 919-921
Singh N, Angel A, Angel B, Shareef BM, Joshi V, Singh DK, Sharma B. 2025. SARS-CoV-2 induced non alkaline pH impacts oxygen binding affinity of hemoglobin. Indian Journal of Respiratory Care, 10.5005./jp-journals-11010-1207
Dheer M, Angel A, Joshi V, Shareef BM, Angel B, Sawhney H, et al. 2025. In-Silico Study on the Role of Epstein Barr Virus to Translocate Tobacco Constituents into Blood to Lead to Oral Cancer. ASM Science Journal, 20 (2), 1-6
Tomar K, Angel A, Joshi V, Angel B, Gadpayle AK, Shareef BM, Khaneja P. 2025. ACE2 Engagement in Virus Internalization Could Lead to Reduced Efficiency of RAAS Pathway Causing Hyponatremia as Negative Prognostic Factor Among COVID-19 patients. Current Trends in Biotechnology and Pharmacy, DOI: 19(3) 2521-2524
Joshi R, Joshi V, Angel B, Angel A, Rao SR. 2025. Determination of molecular diversity based on Internal Transcribed Spacer (ITS) sequences of nrDNA in Commiphora wightii (Art.) Bhandari (Guggul). Research Journal of Biotechnology, DOI: 20(9); 166-175
Shareef BM, Joshi V, Angel B, Angel A, Sharma B. 2025. Enhanced Endoplasmic Reticulum Stress due to Severe Acute Respiratory Syndrome Coronavirus -2 Delta Strain could Induce Cytokine Storm Causing More Clinical Severities/Mortalities. International Journal of Advancement in Life Sciences Research, DOI: 8(3), 94-100
Singh N, Angel A, Joshi V, Angel B, Sharma B. 2025. Study of Carboxyhemoglobin Levels of Patients of Respiratory Viral Infections: An important clinical indicator of severity. Research Journal of Biotechnology, DOI: 20 (8): 197-203
Sharma B, Angel B, Angel A, Joshi V, Shareef BM, Singh N, et al. 2025. Mutations in RNA‐dependent RNA polymerase could be major cause of high pandemic potential of SARS‐CoV‐2: An in‐silico study. Indonesian Journal of Biotechnology. 30(2): 98-106
Chauhan R, Joshi V, Angel B, Angel A, Shareef BM, Chauhan VS, et al. 2025. Interaction of host miRNA and viral RNA of Hepatitis C virus (HCV) as new drug targets against development of Hepato Cellular Carcinoma (HCC). Science & Technology Asia. 30 (2): 256-267
J Jethani J, Samad SA, Choudhary A, Brijwal M, Angel B, Joshi V. 2025. Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India. Virus disease.

https://doi.org/10.1007/s13337-025-00925-x
Sharma B, Angel B, Angel A, Joshi V, Singh N. 2025.Comparative study of pro-Inflammatory and anti-Inflammatory cytokines for understanding the severity in patients infected with SARS-CoV-2 and other Respiratory viruses. Research journal of Biotechnology, 20 (7); 43-46
Joshi V, Sharma B, Angel A, Angel B, Mehta M, Shareef BM. 2025. Presence of Human Metapneumovirus Associated with Severe Acute Respiratory Syndrome Corona Virus 2 and Corresponding Cytokine Levels in Human Patients. Advances in Human Biology

https://doi.org/10.4103/aihb.aihb_16_25
Singh N, Angel A, Joshi V, Angel B, Shareef BM, Sharma B, Peer NM, et al 2025. Possible Role of Antihypertensive Drugs in Blocking the Host Receptor Angiotensin converting Enzyme 2 among Patients of COVID 19. Advances in Human Biology

https://doi.org/10.4103/aihb.aihb_72_24
Shareef BM, Joshi V, Angel B, Angel A, Khaneja P, Dheer M, Sharma B et al. 2025. Study of Concentration of Angiotensin Converting Enzyme-2 (ace-2) Receptor Proteins In Different Age Groups And Gender With Reference To Susceptibility Towards Sars-cov-2. Indian Journal of Respiratory Care, 14(1):72–74
Shareef BM, Joshi V, Angel B, Angel A, Khaneja P, Joshi R. 2025. Intracellular alterations, vacuolization and bypass mechanism by SARS-CoV-2 infection could be the possible basis of respiratory distress and hypoxia. Tissue and cell, 95: 102896
Chouhan R, Angel B, Angel A, Joshi V. 2025. Incidence of Dengue Virus Types in Mosquito Population from Urban, Peri-urban and Rural Settings of Jodhpur, Rajasthan to Predict the Risk of Dengue Haemorrhagic Fever. Journal of Pure and Applied Microbiology, 19(1):470-475
Chaudhary H, Joshi V, Angel B, Angel A. 2025. Implications of proteins and possibilities of vaccine molecule development for Epstein-Barr Virus (EBV) induced oral carcinomas. International Journal of Biotechnology and Microbiology, 7 (4), 81-86.
Ismail MM, Bello SU, Angel B, Ismail M. 2025. The Biophysical Role of Blood Membrane Proteins in Viral Transport: A Review. Dutse Journal of Pure and Applied Sciences (DUJOPAS), 11(4c): 321-328
Khaneja P, Angel A, Angel B, Joshi V, Shareef BM. 2025. Proteomic basis of antigenic shift of Coronavirus from animal to human hosts. Research Journal of Biotechnology, 20 (2), 134-139
Peer NM, Joshi V, Angel B, Angel A, Shareef BM. 2025. Hepatitis C Virus (HCV) and Hepatocellular carcinoma (HCC): Association and molecular causes of HCV transformation to HCC. Research Journal of Biotechnology, 20 (2), 71-78
Haokip L, Vagdevi K, Angel A, Angel B, Joshi V, Dheer M, Sharma P. 2025. Isolation of Selected Epstein - Barr Virus Genes in Swab Samples of Suspected Cases. International Journal of Innovative Science and Research Technology, 10(7), 1426-1430
Chaudhary H, Mavi S, Joshi V, Angel B, Angel A. 2025. Molecular detection and correlation of real-time PCR CT values with clinical manifestations and severity of Influenza A in respiratory illness patients. International Journal of Biotechnology and Microbiology, 7(2), 27-30.
Peer NM, Joshi V, Angel A, Angel B, Shareef BM. 2024. Risk Factors for Progression of Hepatitis C Virus (HCV) Infection to Hepato Cellular Carcinoma (HCC). International Journal of Advancement in Life Sciences Research, 7(4) 146-156
Khaneja P, Angel A, Shareef BM, Barthwal S, Sharma B, Singh N. 2024. Mass spectrometric study of proteins of various variants of severe acute respiratory syndrome coronavirus-2. Advanced Studies in Biology, 16(1), 193-199.
Angel A, Angel B, Khaneja P, Joshi V. 2024. Blood meal intake by Aedes mosquitoes: a simple new method for in vitro experimentation. Journal of Entomological Research, 48 (4), 641-643
Peer NM, Joshi V, Gul I, Angel B, Khan AS, Kumari K, Chitransh A. 2024. Role of Hepatitis C viral proteins influencing functional efficiency of Tumor Suppressor Proteins. Advanced Studies in Biology, 16 (1), 187-192
Khan AS, Angel B, Angel A, Joshi V, Shareef BM. 2024. Consequences of Genomic Mutations and Altered Proteins of SARS-CoV-2 on the Efficacy of Vaccine. Research Journal of Biotechnology, 19(12), 93-100
Khaneja P, Angel A, Joshi V, Angel B, Shareef BM, Barthwal S, Sharma B, et al. 2024. Relative Cellular Organelle Damage Caused by Wuhan and Delta Strains of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Advanced Studies in Biology, 16 (1), 125 – 138
Barthwal S, Angel B, Angel A, Joshi V, Praveen U, Khaneja P, Buvvaji SM, Joshi R. 2024. Serosurveillance of Post vaccination SARS-CoV-2 antibodies in Covishield and Covaxin Vaccinated Subjects. Indian Journal of Community Health, 36(5):661-673
Hasan MR, Sharma P, Mehta Y, Angel A, Angel B, Joshi V, Narang J. 2024. QR-code enabled additive manufactured multiplex-immunosensor to detect DENV serotypes in dengue patient validate with indirect fluorescence antibody test (IFAT). Biosensors and Bioelectronics, 263, 116561
Khan AS, Angel B, Angel A, Joshi V, Shareef BM, Khaneja P, et al. 2024. Stability of Envelope proteins of SARS-CoV-2 Variants could be a choice of new Drug Target. International Journal of Experimental Research and Review, 42, 111-119
Barthwal S, Angel B, Angel A, Joshi V, Praveen U, Bhardwaj UD, Shareef BM, et al. 2024. Evaluating the levels of C-reactive protein (CRP) among post vaccinated subjects of COVID-19 vaccine: A cohort study. Multidisciplinary Science Journal, 6. 10.31893/multiscience.2024240.
Peer NM, Joshi V, Angel A, Angel B, Chauhan VS, Shareef BM, et al. 2024. Characterization of Circulating HCV genotypes: A cohort study in Uttar Pradesh, India. Journal of Pure and Applied Microbiology, 18(2):1057-1063
Khaneja P, Angel A, Joshi V, Angel B, Shareef BM, Dheer M, et al. 2024. In-Vitro studies of Relative Intracellular Alterations caused by Three Variants of Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Journal of Cellular Biotechnology, 10 (2): 125-130
Shareef BM, Joshi V, Angel B, Angel A, Sharma B, Singh N, et al. 2024. Role of Furin activation sites as receptors for infiltration of Severe Acute Respiratory Syndrome Coronavirus-2 into human cells. Journal of Health Science and Medical Research, [S.l.].

Available at: p. e20241051, 2024. ISSN 2630-0559.
Sharma B, Shareef BM, Angel B, Angel A, Joshi V, et al. 2023. Repurposed drug molecule targeting NSP12 protein of SARS-CoV-2: An In-silico study. AIMS Molecular Science, 10 (4): 322-342
Shahid M, Jain P, De A, Angel B, Angel A, Mallick S, Joshi V. 2023. Synthesis, DFT study, molecular docking and larvicidal activity of Chitin inhibitor alanine derived compounds. Polyhedron. 245: 116629
Joshi V, Shareef BM, Angel B, Angel A, Joshi R, et al. 2023. Molecular Basis of Host-Virus Interactions to Explain Relative Transmission and Severity Caused by Omicron and Delta variants of SARS-CoV-2. Journal of Pure Applied and Microbiology, 17(3):1612-1619
Barthwal S, Angel B, Angel A, Joshi V, Shareef BM, et al. 2023.Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains. Asian Pacific Journal of Tropical Medicine. 16(2): 92-94.
Vyas P, Jaiswal S, Joshi V, Angel B, Angel A, Manzoor U, Joshi R. 2023. Analysis of Genetic Diversity among populations of an endangered medicinal plant Commiphora wightii (Arn.) Bhandari (Guggul) using Molecular Markers. Journal of Plant Science Research, 39 (2), 141–152
Angel A, Angel B, Joshi V, Jindal M, Rastogi P, et al. 2022. Correlation between hematological parameters, blood urea level and mortality of Covid-19 patients. International Journal of Health and Allied Sciences. 11:70-74
Khan AS, Angel B, Angel A, Joshi V, Shareef BM, et al. 2022. Study of Khan AS, Angel B, Angel A, Joshi V, Shareef BM, et al. 2022. Study of surface potential and hydrophobicity of amino acids in mutated spike proteins of variants of SARS-CoV-2 and its impact on attachment and internalization of virus with human host cells. Advanced Studies in Biology, 14(1):111-127.
Angel B, Angel A, Joshi V, Jindal M, Rastogi P, Peer N, Shareef BM, Sadhu S, Singh S, Sharma S, Priya K, Chouhan R, Jethani J. 2021. Significance of addressal of clinical investigations of Kidney functions in recovery/mortality of COVID-19 patients: A preliminary study. Biosciences Biotechnology Research Communications. 14 (4): 1985-1991.
Jethani J, Samad S, Kumar P, Angel B, Wig N, Choudhary A, Brijwal M, Kumar L, Dar L. Human metapneumovirus infection in haematopoietic stem cell transplant recipients: a case series. Virus disease. 2021 Mar, DOI: 32(1):140-145

Book Chapters

Bhavya Rani, Bennet Angel, Annette Angel, Vinod Joshi. Staphylococcus aureus infection and its impact on human intestine. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 95-106
Harshita, Bennet Angel, Annette Angel, Vinod Joshi. Meta-Analysis of Prognostic Markers of Breast Cancer and Current Treatment Strategies in India. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 155-165
Hritik Chaudhary, Siddhant Mavi, Vinod Joshi, Bennet Angel, Annette Angel. Role of Anaerobic Respiration Derived Lactic Acid in Severing Malignant Breast Cells. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 199-215
Lunjapikai Haokip, Annette Angel, Vinod Joshi, Bennet Angel. A Study on Epstein–Barr Virus: Host Interaction, Persistence Mechanisms, and Clinical Implications. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 250-266
Megha Kumari, Prity Kumari, Annette Angel, Vinod Joshi, Bennet Angel. Recent update on Epstein-Barr Virus Proteins and its association with Various Oral Malignancies. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 305-320
Kuppa Sree Vagdevi, Annette Angel, Vinod Joshi, Bennet Angel. BZLF1: The Molecular Switch of EBV Reactivation and Its Role in Disease Progression. Emerging Trends and Innovations in Life Sciences: A Book on Research Based Learning Projects of Undergraduate and Postgraduate Studies, SAAR Publications, ISBN – 978-81-989048-2-9, July 2025, pp. 341-350
Farhat Jahan, Annette Angel. Diagnostic Methods of Typhoid: Current Available Methods and Need for New Strategies. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 15-22.
Poorna Khaneja, Neha Singh, Bhawna Sharma, Ambreen Shafaat Khan, Nuzhat Maqbool Peer, Annette Angel, Ramesh Joshi. Increase in Number of Alanine in Non-Structural-Protein 3 (NSP3) of SARS-CoV-2 during Antigenic Shift from Bats to Humans and proposed Repurposed Anti-Alanine Drug. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 23-33
Mehak Sharma, Arun Anand, Nitesh Settee, Annette Angel. Current Trends and Future Possibilities of Improvised Vaccines by Indian Companies in the Context of Circulating Pathogens in the Country. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 34-44.
Sam Yarkpazuah, Shareef BM, Poorna Khaneja, Shilpa Barthwal, Nkeng-Sama Agnes Wa’aa, Grace Andrews, Anthony Semaj Addai, Wilson Nshimiyimana, Annette Angel. Study of Major Organelles Affected in Variants of Concern of SARS-CoV-2. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 45-54.
J Boby Kholiya, Rajkumar Vickyraj Singh, Monika Dheer, Annette Angel. Proteomic Studies of Epstein Barr Virus in Patients with Oral Carcinoma. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 55-60.
Shareef BM, Bhawna Sharma, Neha Singh, Poorna Khaneja, Ambreen Shafaat Khan, Nuzhat Maqbool Peer, Bennet Angel. In-Silico Study of Available Drug Molecules Against Non-Structural Enzymatic Proteins of SARS-COV2 and Some re-purposed Anti-Viral Drug Molecules. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 61-71
Tanya Sharma, Arun Anand, Ravi Kumar, Kashish Singh, Bennet Angel. State-wise Performance Analysis of Pharmaceutical Companies in India. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 72-82.
Faiza Khan, Fauzia, Ankit Chauhan, Aman, Bennet Angel. Biometric Analysis System for Library Users in Higher Education. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 83-94.
Nkeng-Sama Agnes Wa’ah, Shareef BM, Monika Dheer, Lalmalsawmi Sailo, Grace Andrews, Sam Yarkpazuah, Anthony Semaj Addai, Wilson Nshimiyimana, Bennet Angel. Understanding the Importance of Tumor Suppressor Protein p53 in Humans. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 95-105.
Sarthak Sharma, Sadaf Bashir, Vinod Joshi, Metabolic Endocrinal Diseases: Causes and Possibilities of Cure. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 116-126.
Siddharth Guha, Arpan Chakrabarty, Ishzorawar Oberoi, Vinod Joshi. Advancements in Mechanical Engineering for Affordable and Enhanced Products and Services. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 145-156.
Grace Andrews, Shareef BM, Khushbu Kumari, Aarya Chitransh, Nkeng-Sama Agnes Wa’ah, Anthony Semaj Addai, Sam Yarkpazuah, Wilson Nshimiyimana, Bennet Angel. Relative Virulence of Dengue Virus Types and Its Association with Dengue Hemorrhagic Fever. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 157-166.
Wilson Nshimiyimana, Shareef BM, Monika Dheer, Lalmalsawmi Sailo, Anthony Semaj Addai, Nkeng-Sama Agnes Wa’ah, Grace Andrews, Sam Yarkpazuah, Vinod Joshi. Study of Carcinogenic Substances and their Possible Role in Oral Carcinoma. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (B), pp. 176-184.
Nuzhat Maqbool Peer, Neha Singh, Bhawna Sharma, Poorna Khaneja, Ambreen Shafaat Khan, Vinod Joshi. Remdesivir and Risk of Reduced Oxygen Saturation: A Possible Side Effect Leading to Clinical Severity among COVID-19 Patients. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (C), pp. 163-168.
Anthony Semaj Addai, Shareef BM, Khushbu Kumari, Aarya Chitransh, Nkeng-Sama Agnes Wa’ah, Grace Andrews, Sam Yarkpazuah, Wilson Nshimiyimana, Vinod Joshi. Study of Aedes Mosquito Proteins and their Role in Dengue Fever and Dengue Hemorrhagic Fever. National Conference on Contemporary Advances in Interdisciplinary Sciences, (NCCAIS-2024), ISBN 978-81-973556-8-4, SAAR Publications, India. April, 2024, Vol. 3 (C), pp. 205-216.
Angel A, Angel B, Yadav N, Narang J, Yadav SS, Joshi V. Aedes Mosquitoes: The Universal Vector in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 1-17.
Angel A, Angel B, Yadav N, Narang J, Yadav SS, Joshi V. The Aedes Fauna: Different Aedes Species Inhabiting the Earth in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 21-54.
Joshi V, Angel B, Angel A, Yadav N, Narang J. Viral Pathogens: A General Account in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 81-94.
Angel B, Yadav N, Narang J, Angel A, Joshi V. Dengue Fever: A Viral Hemorrhagic Fever of Global Concern in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 99-139.
Yadav N, Angel B, Narang J, Yadav SS, Joshi V. Chikungunya Fever: Emergence and Reality in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 164-178.
Angel B, Yadav N, Narang J, Yadav SS, Angel A, Joshi V. Zika: An Ancient Virus Incipient into New Spaces in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti, Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 187-204.
Yadav N, Angel B, Narang J, Yadav SS, Joshi V, Angel A. Yellow Fever: Emergence and Reality in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 211-226.
Joshi V, Angel A, Angel B, Yadav N, Narang J, Yadav S. West Nile Virus: The Silent Neuro-Invasive Terror in Small Bite, Big Threat: Deadly Infections of the Aedes Aegypti; Jenny Stanford Publishing Pvt. Ltd., Singapore, 2020. ISBN 978-981-4800-86-0 (Hardcover); ISBN 978-1-003-00329-8 (ebook); pages: 233-245.

Projects

The faculties working in the Centre have been awarded with Government funds as well as Institutional funds (Sharda Seed grant), the details of which are as follows:

Extramural grants (Sharda affiliated):

Bioinformatics study of spatial distribution of variants of SARS CoV-2 & other respiratory viruses in India: In-Silico and wet lab studies of structural & non-structural protein mutations and their compatibility with vaccine/drug molecules

PI: Dr.Annette Angel

Agency: Indian Council of Medical Research, GOI

Year : 2023-2026
A A Case-Control study on large hospital data base to implicate role of co- morbidities causing mortality of COVID-19 patients and development of a new RT-PCR based algorithm as predictor of clinical outcome

PI: Dr.Bennet Angel

Agency: Indian Council of Medical Research, GOI

Year : 2022-2025
A A Health Informatics Study of Association of Hepatitis C Viral Proteins and Human Tumor Suppressing Proteins Leading to Hepato-Cellular Carcinoma

PI: Dr.Vinod Joshi

Funding Agency: Indian Council of Medical Research, GOI

Year : 2020-2023

Institutional funds (Sharda Seed grant)

Faculty Seed fund scheme:

Study of Reduced Oxygen Affinity of Haemoglobin molecule, caused by COVID-19 infection and other Respiratory viruses, as the possible cause of Respiratory Distress/Mortality of patients and its therapeutic normalization using repurposed oxidising drug

PI: Dr.Annette Angel

Co-PI: Dr.Rajesh Thakur, Dept of Biochemistry, Sharda School of Medical Sciences & Research

Year: 2021-2022
Study of mixed infections of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV2) and other Respiratory Viruses to lead to severity/mortality among patients

PI: Dr.Bennet Angel

Co-PI: Dr Sneha Mohan, Dept of Microbiology, Sharda School of Medical Sciences & Research

Year: 2021-2022
Development of potential vaccine target for SARS-CoV-2 infection

PI: Prof.Vinod Joshi

Year: 2025-2026

Student innovation Seed fund scheme:

Isolation of Virucidal, Anti-parasitic & larvicidal component from Calotropis procera against Anopheline and Aedes mosquitoes
Students:
- • Ishaan Mehta, 2021001669, MSc Biotechnology (Batch of 2021-2023)
- • Varun Bharadwaj, 2021443050, MSc Microbiology (Batch of 2021-2023)
Year: 2022-2023

Patents

Kumbhat S. Miura N, Joshi V, Shankaran DR, Gobi KV. 2016. Affinity Biosensor for Dopamine (Patent No. 271054, Grant date: 29.1.2016)
Jain P, Shahid M, Angel B, De A, Angel A, Joshi V. 2023. Organo-Copper Complex and a Larvicidal Composition comprising the same. (Patent no. 202311010155, published 5.5.2023)
Angel B, Angel A, Joshi V, Mehta I, Bhardwaj V, Shareef BM, Joshi R, Khaneja P.2023. A High Efficacy Larvicidal Formulation from Calotropis procera. (Patent number. 202311059367, Published on 6.10.2023)
Joshi V, Angel A, Angel B, Joshi R, Shareef BM. 2024. Vaccine Targeting Conserved Region of Coronavirus (Provisional Indian Patent Application no 202411030338, filed on April 15, 2024).
Angel A, Khan AS, Shareef BM, Joshi V, Angel B, Joshi R. An Envelope Protein and Membrane Glycoprotein Based Vaccine Composition Against Sars-cov-2 (Patent Application no. No.202511013009 A published on 28.2.25).
Joshi R, Singh P, Singh S, Joshi V, Rao SR, Angel A, Angel B. Cordyceps militaris, a novel bio-larvicide against dengue and malaria vectors (Patent no. 202411090067 A, Published on 6.12.24)
Joshi R, Singh P, Singh S, Joshi V, Rao SR, Angel A, Angel B. Method for preparation of Cordyceps militaris with high cordycepin content. (Patent no. 202511081806 A, published on 17.10.2025)
Shareef BM, Joshi V, Angel A, Angel B, Sharma B, Joshi R, Khaneja P. 2025. An Adenosine analogue based compound against Severe Acute Respiratory Syndrome-Coronavirus-2 (Patent no. 202411032512, filed on 25.10. 2025).

Collaboration

We are a group of scientists cum academicians with expertise in the field of medical virology and immunology. In the past, we have been associated with various organizations like Max Healthlife, Delhi; Jamia Hamdard, Delhi; AIIMS, Jodhpur, ICMR institute (DMRC, Jodhpur); Breast Cancer Hub, USA, World society of Virology, Egypt, RSTMH, UK and others. We are open for any collaboration with Institutes of National and International level. Please feel free to interact us via email.

Past MOU's

For research activities on Breast Cancer under the MoU signed between Dr. Lopamudra Das Roy, Founder and President (Cancer Research Professor) Breast Cancer Hub Corporation, North Carolina, U.S.A and Dr. Vinod Joshi, Professor Department of Life Sciences, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
For research and academic activities between Royal Society of Tropical medicine and Hygiene, UK (Dr Tamar Ghosh, CEO) and Dr. Vinod Joshi, Professor Department of Life Sciences, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
For research activities between SO Young Life Science Corporation, USA (Dr Avinash Seth, CEO) and Dr. Vinod Joshi, Professor Department of Life Sciences, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

The Centre of Excellence is designed as per an upgraded BSL-2 level laboratory with designated places for sample handling, RNA/DNA extraction, Master mix preparation room, PCR set up, Proteomics work bench, serology workbench, cell culture work bench, insectary etc. The Centre also has a dedicated Bioinformatics room.

CEVI Entrance

Gallery Area

Biosafety Zone

Containment Area

Research Streams Display

Sample Reception Area

Donning & Doffing Room

Sample Aliquoting Room

DNARNA Extraction Room

Master Mix Preparation Room

RT-PCR Room

Incubation Room

Cell Culture Room

Microscopy Room

Chemical's Room

Proteomics Work Area

Serological Work Area

Shower Room

Bioinformatics Room

Insectory

The Centre of Excellence has dedicated Biosafety Cabinets for sample aliquoting, master mix preparation and cell culture. It has high end microscopy; Zeiss Vert.AI AXI10 microscope, Deep freezer (-80˚C), Qiagen’s Real Time RT-PCR, CO2 incubator and many other major and minor equipment’s required for virology, genomics, proteomics, immunology related work. The centre also has a dedicated bioinformatics work bench and also has facility for maintenance of Aedes mosquitoes (insectary).